Event Location
2250 EB


Dr. Zhen Qiu

Assistant Professor
Department of Biomedical Engineering

Institute for Quantitative Health and Science and Engineering

Michigan State University

Thursday, February 22, 2018

3:00 p.m. - 4:00 p.m.

2250 EB

“Micro-systems enabled Miniaturized Microendoscope for Clinical Applications ”


MEMS based microendoscopes have become important imaging tools for early cancer diagnosis and precise tumor resection. Due to various technical challenges, few microendoscopes have been translated to clinics or applied to human patients. Through synergistic collaborations, we have developed novel MEMS scanner enabled microendoscopic multispectral (640nm to 780nm) three- dimensional dual-axis confocal fluorescent imaging system for translational applications, including early cancer detection and staging on colorectal cancer, molecular imaging guided surgical navigation on head and neck cancer. Based on dual-axis confocal microscopic architecture, we have miniaturized the imaging system with compact form-factor by integrating micro-optics and a patterned gold coated MEMS scanners, which have been custom-made and mass-produced in the nanofabrication foundry. The metal coating of the scanning mirror provide over 80% high reflectivity over near infra-red range. Both axes of the MEMS scanner could perform large tilting angle (> 6 degree mechanical scan angle) at DC and resonant mode. By advanced computational imaging approach, we have achieved real-time cross-sectional imaging in either raster or lissajous pattern scanning with fast frame rate (> 10 Hz) with large field-of-view (> 600 microns). Advanced real-time mosaicing algorithm has been developed to achieve broader view in millimeter scale. By utilizing molecular contrast probes conjugated with fluorescence dye, we have successfully demonstrated multi-spectral ex-vivo and in-vivo imaging on small animal tumor models and human tissue specimens, aimed for both early cancer detection and molecular imaging guided surgical navigation.

Zhen Qiu received the Bachelor degree from the Department of Precision Instrument, Tsinghua University, Beijing, China, and the Ph.D. degree from the Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI. He finished his post-doctoral training in the School of Medicine, Stanford University, CA. He is an Assistant Professor in the Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, MI. His research interests include biomedical optics, MEMS/MOEMS, multi-modal targeted imaging, wearable and implantable medical devices, ultrafast laser applications. He aims to study both cancer biology and translational medicine with custom-made micro-systems enabled ultra-thin in-vivo sensing/imaging tools. His current work is mainly focused on miniaturized optical imaging system development for early cancer detection and imaging guided surgical navigation, such as wide-field imaging guided micro-scanner based confocal microendoscope, multi-photon/SHG handheld microscope, surface-enhanced Raman spectroscopy. 

Faculty Host:  Dr. Wen Li (

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